Image:Virus Replication large.svg

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Description

A diagram of influenza viral cell invasion and replication.

Source

Scaled up from Image:Virus Replication.svg by User:YK Times, who redrew from w:Image:Virusreplication.png using Adobe Illustrator.

Date

March 5, 2007

Author

User:YK Times

Permission
( Reusing this image)

see below

Other versions w:Image:Virusreplication.png, Image:Virus Replication.svg

Description from Scheme of Influenza A virus replication (NCBI): "A virion attaches to the host cell membrane via HA and enters the cytoplasm by receptor-mediated endocytosis (STEP 1), thereby forming an endosome. A cellular trypsin-like enzyme cleaves HA into products HA1 and HA2 (not shown). HA2 promotes fusion of the virus envelope and the endosome membranes. A minor virus envelope protein M2 acts as a ion channel thereby making the inside of the virion more acidic. As a result, the major envelope protein M1 dissociates from the nucleocapsid and vRNPs are translocated into the nucleus (STEP 2) via interaction between NP and cellular transport machinery. In the nucleus, the viral polymerase complexes transcribe (STEP 3a) and replicate (STEP 3b) the vRNAs. Newly synthesized mRNAs migrate to cytoplasm (STEP 4) where they are translated. Posttranslational processing of HA, NA, and M2 includes transportation via Golgi apparatus to the cell membrane (STEP 5b). NP, M1, NS1 (nonstructural regulatory protein - not shown) and NEP (nuclear export protein, a minor virion component - not shown) move to the nucleus (STEP 5a) where bind freshly synthesized copies of vRNAs. The newly formed nucleocapsids migrate into the cytoplasm in a NEP-dependent process and eventually interact via M1 with a region of the cell membrane where HA, NA and M2 have been inserted (STEP 6). Then the newly synthesized virions bud from infected cell (STEP 7). NA destroys the sialic acid moiety of cellular receptors, thereby releasing the progeny virions."

Licensing

I, the copyright holder of this work, hereby publish it under the following licenses:
GNU head Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation license, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled " GNU Free Documentation license".

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File history

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Date/Time Dimensions User Comment
current 17:26, 16 March 2008 925×852 (310 KB) Photohound ({{Information |Description=A diagram of influenza viral cell invasion and replication. |Source=Scaled up from Image:Virus Replication.svg by User:YK Times, who redrew from w:Image:Virusreplication.png using Adobe Illustrator. |Date=March 5, 2)
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